Ayala is a clinical stage precision oncology company dedicated to developing targeted therapies for genomically defined, clinically underserved cancers.

We look to target rare and unique cancers, in which the Notch activation pathway has been dysregulated. Notch is a proven oncogenic driver in defined cancers. Our focus is on inhibiting the Notch activating pathway with potentially best in class gamma secretase inhibitors (GSIs).

In 2017, we entered into an exclusive worldwide license agreement with Bristol-Myers Squibb for their gamma secretase inhibitors in development for the potential treatment of cancers with altered Notch genes.

Our lead product, AL101, has completed preclinical and phase 1 studies. A phase 2 study (ACCURACY) for AL101 in patients with adenoid cystic carcinoma (ACC) bearing activating Notch mutations is ongoing. Additional two Phase 2 studies are planned in patients with Triple Negative Breast Cancer (TNBC) and in patients with T-cell Acute Lymphoblastic Leukemia (T-ALL), both in patients bearing activating Notch alterations.

In 2018, we entered a deal with Novartis to develop and commercialize AL102 in combination with BCMA-targeting agents in multiple myeloma. In addition, Ayala is evaluating AL102 as an inhibitor of the Notch pathway in additional indications.

We aim to match the right patient to the right drug, and hope to achieve the promise of precision oncology: deliver better clinical outcomes and greater benefits for patients, caregivers and healthcare providers.

Learn about our Notch pipeline
AL101 Phase 2 in ACC

Our mission

At Ayala, we are focused on developing best in class targeted therapies for cancer patients with an activated Notch pathway. We target genomically-defined, clinically underserved cancers where we can have the most impact.

We are guided by strongly held values:


Improve outcomes in patients with underserved cancers


Be compassionate to the patients we serve


To consistently be open, honest, and ethical in all our endeavors


To efficiently bring innovative products to market for the benefit of our patients and shareholders

Our people